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Role of membrane features on the permeability behavior of polymersomes and the potential impacts on drug encapsulation and release
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SYSNO ASEP 0572240 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Role of membrane features on the permeability behavior of polymersomes and the potential impacts on drug encapsulation and release Author(s) de Oliveira, F. A. (BR)
da Silva Batista, C. C. (BR)
Černoch, Peter (UMCH-V) RID, ORCID
Sincari, Vladimir (UMCH-V) ORCID, RID
Jäger, Alessandro (UMCH-V) RID, ORCID
Jäger, Eliezer (UMCH-V) ORCID, RID
Giacomelli, F. C. (BR)Source Title Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 24, č. 5 (2023), s. 2291-2300Number of pages 10 s. Language eng - English Country US - United States Keywords block copolymers ; polymersomes ; permeability Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects GC20-15479J GA ČR - Czech Science Foundation (CSF) GJ20-13946Y GA ČR - Czech Science Foundation (CSF) GJ20-15077Y GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000982499900001 EID SCOPUS 85156273914 DOI https://doi.org/10.1021/acs.biomac.3c00162 Annotation Self-assembled bilayer structures such as those produced from amphiphilic block copolymers (polymersomes) are potentially useful in a wide array of applications including the production of artificial cells and organelles, nanoreactors, and delivery systems. These constructs are of important fundamental interest, and they are also frequently considered toward advances in bionanotechnology and nanomedicine. In this framework, membrane permeability is perhaps the most important property of such functional materials. Having in mind these considerations, we herein report the manufacturing of intrinsically permeable polymersomes produced using block copolymers comprising poly[2-(diisopropylamino)-ethyl methacrylate] (PDPA) as the hydrophobic segment. Although being water insoluble at pH 7.4, its pKa(PDPA) ∼ 6.8 leads to the presence of a fraction of protonated amino groups close to the physiological pH, thus conducting the formation of relatively swollen hydrophobic segments. Rhodamine B-loaded vesicles demonstrated that this feature confers inherent permeability to the polymeric membrane, which can still be modulated to some extent by the solution pH. Indeed, even at higher pH values where the PDPA chains are fully deprotonated, the experiments demonstrate that the membranes remain permeable. While membrane permeability can be, for instance, regulated by introducing membrane proteins and DNA nanopores, examples of membrane-forming polymers with intrinsic permeability have been seldom reported so far, and the possibility to regulate the flow of chemicals in these compartments by tuning block copolymer features and ambient conditions is of due relevance. The permeable nature of PDPA membranes possibly applies to a wide array of small molecules, and these findings can in principle be translocated to a variety of disparate bio-related applications. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2025 Electronic address https://pubs.acs.org/doi/10.1021/acs.biomac.3c00162
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