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Liquid resorbable nanofibrous surgical mesh: a proof of a concept
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SYSNO ASEP 0569559 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Liquid resorbable nanofibrous surgical mesh: a proof of a concept Author(s) East, B. (CZ)
Woleský, J. (CZ)
Divín, R. (CZ)
Otáhal, M. (CZ)
Vocetková, Karolína (UEM-P) ORCID
Sovková, Věra (UEM-P) ORCID
Hefka Blahnová, Veronika (UEM-P)
Koblížek, M. (CZ)
Kubový, P. (CZ)
Nečasová, A. (CZ)
Staffa, A. (CZ)
de Beaux, A.Ch. (GB)
Lorenzová, J. (CZ)
Amler, E. (CZ)Source Title Hernia. - : Springer - ISSN 1265-4906
Roč. 26, č. 2 (2022), s. 557-565Number of pages 9 s. Language eng - English Country FR - France Keywords hernia ; mesh ; nanofibres ; liquid mesh OECD category Biomaterials (as related to medical implants, devices, sensors) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000778070900001 EID SCOPUS 85127383730 DOI 10.1007/s10029-022-02582-1 Annotation Background Surgical mesh is widely used not only to treat but also to prevent incisional hernia formation. Despite much effort by material engineers, the 'ideal' mesh mechanically, biologically and surgically easy to use remains elusive. Advances in tissue engineering and nanomedicine have allowed new concepts to be tested with promising results in both small and large animals. Abandoning the concept of a pre-formed mesh completely for a 'pour in liquid mesh' has never been tested before. Materials and methods Thirty rabbits underwent midline laparotomy with closure using an absorbable suture and small stitch small bites technique. In addition, their abdominal wall closure was reinforced by a liquid nanofibrous scaffold composed of a fibrin sealant and nanofibres of poly-epsilon-caprolactone with or without hyaluronic acid or the sealant alone, poured in as an 'onlay' over the closed abdominal wall. The animals were killed at 6 weeks and their abdominal wall was subjected to histological and biomechanical evaluations. Results All the animals survived the study period with no major complication. Histological evaluation showed an eosinophilic infiltration in all groups and foreign body reaction more pronounced in the groups with nanofibres. Biomechanical testing demonstrated that groups treated with nanofibres developed a scar with higher tensile yield strength. Conclusion The use of nanofibres in a liquid form applied to the closed abdominal wall is easy to use and improves the biomechanical properties of healing fascia at 6 weeks after midline laparotomy in a rabbit model. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://link.springer.com/article/10.1007/s10029-022-02582-1
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