CHICKEN DDNTFR23 AS A CANDIDATE RECEPTOR FOR AN ALV-F SUBGROUP

0567919 - ÚMG 2023 RIV CZ eng A - Abstract
Gáliková, Eliška - Přikryl, David - Pecnová, Lubomíra - Kučerová, Dana - Morisson, M. - Hejnar, Jiří
CHICKEN DDNTFR23 AS A CANDIDATE RECEPTOR FOR AN ALV-F SUBGROUP.
Czech Chemical Society Symposium Series. Roč. 20, č. 6 (2022), č. článku P-64. ISSN 2336-7202.
[Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /1./. 30.11.2022-02.12.2022, Kutná Hora]
R&D Projects: GA MŠMT(CZ) LX22NPO5103
Institutional support: RVO:68378050
Keywords : avian leukosis virus * virus receptor * endogenous retrovirus
OECD category: Virology
http://www.ccsss.cz/index.php/ccsss/issue/view/37/67

Avian leukosis virus subgroups (ALV) A, B, C, D, E, J, and K are grouped according to their antigenic reactivity, superinfection interference, and cell receptor usage. However, these characteristics remain to be determined for the endogenous F subgroup. Therefore, we characterized the cell receptor usage for the F subgroup. We constructed arecombinant avian leukosis virus with the F subgroup envgene that replicates only in chicken cells. The F subgroup did not share the cell receptor usage with any other described ALV subgroup by the superinfection interference. We identifiedDDTNFR23 protein as the receptor in chicken and pheasant cells for the F subgroup by an infection of chicken/hamster radiation hybrids. Taken together, we provide amolecular characterization of the F subgroup avian leukosis virus and enhance our knowledge of receptor usage diversification within a closely related virus.
Permanent Link: https://hdl.handle.net/11104/0339184