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NMR-BASED METABOLOMIC ANALYSIS OF BLOOD PLASMA AS A PANCREATIC CANCER DIAGNOSTIC TOOL
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SYSNO ASEP 0566927 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title NMR-BASED METABOLOMIC ANALYSIS OF BLOOD PLASMA AS A PANCREATIC CANCER DIAGNOSTIC TOOL Author(s) Michálková, Lenka (UCHP-M) RID, ORCID, SAI
Horník, Štěpán (UCHP-M) ORCID, RID, SAI
Setnička, V. (CZ)
Sýkora, Jan (UCHP-M) RID, ORCID, SAI
Bunganič, B. (CZ)Article number SE-8 Source Title Book of Abstracts. - Zagreb : Croatian Chemical Society, 2022 / Bregović N. ; Namjesnik D. ; Novak P. ; Vuković J.P. - ISBN 978-953-8334-04-7
S. 61Number of pages 1 s. Publication form Online - E Action Magnetic Moments in Central Europe 2022 Event date 01.06.2022 - 04.06.2022 VEvent location Primošten Country HR - Croatia Event type EUR Language eng - English Country HR - Croatia Keywords blood plasma ; nmr metabolomic ; pancreatic cancer OECD category Environmental sciences (social aspects to be 5.7) R&D Projects TK02010035 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Institutional support UCHP-M - RVO:67985858 Annotation In this work, 1H NMR metabolomic analysis of blood plasma was used as an alternative approach for early PC diagnosis in RODM patients. Based on concentration profile of 58 metabolites, a discrimination of PC patients from long-term T2DM patients was achieved. A specific biomarker panel of eight metabolites was proposed and successfully tested for PC diagnosis against T2DM patients and healthy controls. Moreover, a prediction model for the identification of risk individuals for PC development in RODM group was developed and the patients likely suffering from pancreatogenic diabetes were identified. Six of 59 RODM patients had similar metabolic characteristics as PC patients and their health conditions were therefore re-examined.
The found pathological changes correlated reasonably with our findings. Recent results also indicated subtle metabolic changes among individual PC clinical stages that could be used for their differentiation in future.Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2023
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