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A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010–2019)
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SYSNO ASEP 0565610 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010–2019) Author(s) Nahar, Lutfun (UEB-Q) ORCID
Önder, A. (TR)
Sarker, S. D. (GB)Number of authors 3 Source Title Phytochemical Analysis. - : Wiley - ISSN 0958-0344
Roč. 31, č. 4 (2020), s. 413-457Number of pages 45 s. Language eng - English Country GB - United Kingdom Keywords analysis ; cannabinoids ; Cannabis ; Cannabis sativa ; detection ; hempLC-MSLC-PDAliquid chromatography (LC)marijuana ; hplc ; uhplc ; uplc OECD category Biochemistry and molecular biology Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000503022500001 EID SCOPUS 85076761391 DOI 10.1002/pca.2906 Annotation Introduction: Organic molecules that bind to cannabinoid receptors are called cannabinoids, and they have similar pharmacological properties like the plant, Cannabis sativa L. Hyphenated liquid chromatography (LC), incorporating high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC, also known as ultrahigh-performance liquid chromatography, UHPLC), usually coupled to an ultraviolet (UV), UV-photodiode array (PDA) or mass spectrometry (MS) detector, has become a popular analytical tool for the analysis of naturally occurring cannabinoids in various matrices. Objective: To review literature on the use of various LC-based analytical methods for the analysis of naturally occurring cannabinoids published since 2010. Methodology: A comprehensive literature search was performed utilising several databases, like Web of Knowledge, PubMed and Google Scholar, and other relevant published materials including published books. The keywords used, in various combinations, with cannabinoids being present in all combinations, in the search were Cannabis, hemp, cannabinoids, Cannabis sativa, marijuana, analysis, HPLC, UHPLC, UPLC, quantitative, qualitative and quality control. Results: Since 2010, several LC methods for the analysis of naturally occurring cannabinoids have been reported. While simple HPLC-UV or HPLC-UV-PDA-based methods were common in cannabinoids analysis, HPLC-MS, HPLC-MS/MS, UPLC (or UHPLC)-UV-PDA, UPLC (or UHPLC)-MS and UPLC (or UHPLC)-MS/MS, were also used frequently. Applications of mathematical and computational models for optimisation of different protocols were observed, and pre-analyses included various environmentally friendly extraction protocols. Conclusions: LC-based analysis of naturally occurring cannabinoids has dominated the cannabinoids analysis during the last 10 years, and UPLC and UHPLC methods have been shown to be superior to conventional HPLC methods. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2023 Electronic address https://doi.org/10.1002/pca.2906
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