Track Structure-Based Simulations on DNA Damage Induced by Diverse Isotopes

0565022 - ÚJF 2023 RIV CH eng J - Journal Article
Kundrát, Pavel - Friedland, W. - Baiocco, G.
Track Structure-Based Simulations on DNA Damage Induced by Diverse Isotopes.
International Journal of Molecular Sciences. Roč. 23, č. 22 (2022), č. článku 13693. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA21-06451S; GA MŠMT EF16_019/0000728
Institutional support: RVO:61389005
Keywords : ionizing radiation * isotopes * track structure * DNA damage * Monte Carlo simulations * analytical functions
OECD category: Biochemistry and molecular biology
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms232213693

Diverse isotopes such as H-2, He-3, Be-10, C-11 and C-14 occur in nuclear reactions in ion beam radiotherapy, in cosmic ray shielding, or are intentionally accelerated in dating techniques. However, only a few studies have specifically addressed the biological effects of diverse isotopes and were limited to energies of several MeV/u. A database of simulations with the PARTRAC biophysical tool is presented for H, He, Li, Be, B and C isotopes at energies from 0.5 GeV/u down to stopping. The doses deposited to a cell nucleus and also the yields per unit dose of single- and double-strand breaks and their clusters induced in cellular DNA are predicted to vary among diverse isotopes of the same element at energies < 1 MeV/u, especially for isotopes of H and He. The results may affect the risk estimates for astronauts in deep space missions or the models of biological effectiveness of ion beams and indicate that radiation protection in C-14 or Be-10 dating techniques may be based on knowledge gathered with C-12 or Be-9.
Permanent Link: https://hdl.handle.net/11104/0336585