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Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium
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SYSNO ASEP 0560435 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium Author(s) Křenek, T. (CZ)
Stich, T. (DE)
Docheva, D. (DE)
Mikysek, Petr (GLU-S) SAI, ORCID
Koštejn, Martin (UCHP-M) RID, SAI, ORCID
Jandová, Věra (UCHP-M) RID, ORCID, SAI
Fajgar, Radek (UCHP-M) RID, ORCID, SAI
Pola, M. (CZ)
Kovářík, T. (CZ)
Moskal, D. (CZ)
Forejtová, M. (CZ)
Pola, Josef (UCHP-M) RID, ORCID, SAIArticle number 128820 Source Title Surface and Coatings Technology. - : Elsevier - ISSN 0257-8972
Roč. 447, October (2022)Number of pages 10 s. Publication form Print - P Language eng - English Country CH - Switzerland Keywords Calcium titanate coat ; Hydrolysis ; Micro/nanostructured oxidic titanium ; hMSCs ; Osteogenic differentiation ; DMEM-TiO2 interactions ; Self-organized precipitation of DMEM OECD category Mineralogy Method of publishing Limited access Institutional support GLU-S - RVO:67985831 ; UCHP-M - RVO:67985858 UT WOS 000853444000001 EID SCOPUS 85137110806 DOI 10.1016/j.surfcoat.2022.128820 Annotation This study characterized laser-deposited CaTiO3 coats on several substrates by electron microscopy, X-ray diffraction, and Raman spectra. The hydrolytic stability of such coats exposed to ambient air and immersed into culture and osteogenic media has been respectively assessed by X-ray photoelectron spectra and energy dispersive X-ray analysis. It is shown these coats on titanium and micro/nanostructured oxidic titanium are not stable in air and culture or osteogenic media where they undergo hydrolysis and Ca leakage. The role of this hydrolysis is assessed and discussed in terms of not yet acknowledged complexation of the developing TiO2 surface with constituents of Dulbecco's Modified Eagle's medium. The effect of the deposited and additionally heated CT coatings on human mesenchymal stem cells is assessed regarding survival, proliferation and differentiation towards the osteogenic lineage in osteogenic medium. It is also stressed that the identified CaTiO3 hydrolysis in air and aquatic media seriously impacts the interpretation of bioactivity and physicochemical, catalytic and photocatalytic properties of CaTiO3 surfaces, which has not been yet admitted and led to erroneous conclusions in many previous studies. Workplace Institute of Geology Contact Jana Popelková, popelkova@gli.cas.cz, Sabina Janíčková, Tel.: 233 087 272 Year of Publishing 2023 Electronic address https://www.sciencedirect.com/science/article/pii/S0257897222007411
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