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Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System
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SYSNO ASEP 0560226 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Development of the Cerebrospinal Fluid in Early Stage after Hemorrhage in the Central Nervous System Author(s) Kelbich, P. (CZ)
Hejčl, Aleš (UEM-P) RID, ORCID
Krejsek, J. (CZ)
Radovnický, T. (CZ)
Matuchová, I. (CZ)
Lodin, J. (CZ)
Špička, J. (CZ)
Sameš, M. (CZ)
Procházka, J. (CZ)
Hanuljaková, E. (CZ)
Vachata, P. (CZ)Article number 300 Source Title Life. - : MDPI
Roč. 11, č. 4 (2021)Number of pages 11 s. Language eng - English Country CH - Switzerland Keywords CNS haemorrhage ; inflammation in CNS ; cerebrospinal fluid ; total protein in CSF OECD category Clinical neurology Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000643221400001 EID SCOPUS 85104077851 DOI https://doi.org/10.3390/life11040300 Annotation Extravasation of blood in the central nervous system (CNS) represents a very strong damaged associated molecular patterns (DAMP) which is followed by rapid inflammation and can participate in worse outcome of patients. We analyzed cerebrospinal fluid (CSF) from 139 patients after the CNS hemorrhage. We compared 109 survivors (Glasgow Outcome Score (GOS) 5-3) and 30 patients with poor outcomes (GOS 2-1). Statistical evaluations were performed using the Wilcoxon signed-rank test and the Mann-Whitney U test. Almost the same numbers of erythrocytes in both subgroups appeared in days 0-3 (p = 0.927) and a significant increase in patients with GOS 2-1 in days 7-10 after the hemorrhage (p = 0.004) revealed persistence of extravascular blood in the CNS as an adverse factor. We assess 43.3% of patients with GOS 2-1 and only 27.5% of patients with GOS 5-3 with low values of the coefficient of energy balance (KEB < 15.0) in days 0-3 after the hemorrhage as a trend to immediate intensive inflammation in the CNS of patients with poor outcomes. We consider significantly higher concentration of total protein of patients with GOS 2-1 in days 0-3 after hemorrhage (p = 0.008) as the evidence of immediate simultaneously manifested intensive inflammation, swelling of the brain and elevation of intracranial pressure. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://www.mdpi.com/2075-1729/11/4/300
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