Number of the records: 1
Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins
- 1.
SYSNO ASEP 0559934 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins Author(s) Jakovljevic, A. (RS)
Tucic, M. (RS)
Blažíková, Michaela (UMG-J)
Korenic, A. (RS)
Missirlis, Y. F. (GR)
Stamenkovic, V. (RS)
Andjus, P. (RS)Number of authors 7 Article number 1345 Source Title Cells. - : MDPI
Roč. 10, č. 6 (2021)Number of pages 20 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords extracellular matrix ; perineuronal nets ; tenascin-C ; synaptic plasticity ; mechanotransduction ; neurogenesis ; super-resolution microscopy Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF18_046/0016045 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1220 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000667372300001 DOI 10.3390/cells10061345 Annotation The extracellular matrix (ECM) of the brain plays a crucial role in providing optimal conditions for neuronal function. Interactions between neurons and a specialized form of ECM, perineuronal nets (PNN), are considered a key mechanism for the regulation of brain plasticity. Such an assembly of interconnected structural and regulatory molecules has a prominent role in the control of synaptic plasticity. In this review, we discuss novel ways of studying the interplay between PNN and its regulatory components, particularly tenascins, in the processes of synaptic plasticity, mechanotransduction, and neurogenesis. Since enhanced neuronal activity promotes PNN degradation, it is possible to study PNN remodeling as a dynamical change in the expression and organization of its constituents that is reflected in its ultrastructure. The discovery of these subtle modifications is enabled by the development of super-resolution microscopy and advanced methods of image analysis. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2023 Electronic address https://www.mdpi.com/2073-4409/10/6/1345
Number of the records: 1