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Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta
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SYSNO ASEP 0555132 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Differences in inflammatory responses of rainbow trout infected by two genotypes of the myxozoan parasite Ceratonova shasta Author(s) Taggart-Murphy, L. (US)
Alama-Bermejo, Gema (BC-A) RID, ORCID
Dolan, B. (US)
Takizawa, F. (JP)
Bartholomew, J. (US)Number of authors 5 Article number 103829 Source Title Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
Roč. 114, JAN 2021 (2021)Number of pages 8 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords ceratomyxa-shasta ; chinook salmon ; myxosporean parasite ; resistant chinook ; gene-expression ; host factors ; river ; tshawytscha ; population ; virulence ; Salmonid ; Cytokine ; Immunoglobulin ; Fish disease ; Intestine Subject RIV GJ - Animal Vermins ; Diseases, Veterinary Medicine OECD category Veterinary science R&D Projects GP14-28784P GA ČR - Czech Science Foundation (CSF) GX19-28399X GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000588061100023 EID SCOPUS 85089903185 DOI 10.1016/j.dci.2020.103829 Annotation Two genotypes of the intestinal parasite Ceratonova shasta infect Oncorhynchus mykiss: genotype 0 results in a chronic infection with low mortality while genotype IIR causes disease with high mortality. We determined parasite load and the relative expression of six immune factors (IgT, IgM, IL-6, IL-8, IL-10, IFNG) in fish infected with either genotype over 29 days post-exposure. In genotype IIR infections the host responded with upregulation of inflammatory and regulatory cytokines. In contrast, genotype 0 infection did not elicit an inflammatory response and expression of IFNG and IL-10 was lower. Antibody expression was upregulated in both infections but appeared to have limited efficacy in the virulent genotype IIR infections. Histologically, in genotype 0 infections the parasite migrated through the tissue layers causing inflammation but minimal damage to the mucosal epithelium, which contrasts with the severe pathology found in genotype IIR infections. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2022 Electronic address https://www.sciencedirect.com/science/article/pii/S0145305X20303840?via%3Dihub
Number of the records: 1