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Non-Enzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces
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SYSNO ASEP 0554850 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Non-Enzymatic, Template-Free Polymerization of 3',5' Cyclic Guanosine Monophosphate on Mineral Surfaces Author(s) Šponer, Judit E. (BFU-R) RID, ORCID
Šponer, Jiří (BFU-R) RID, ORCID
Výravský, J. (CZ)
Šedo, O. (CZ)
Zdráhal, Z. (CZ)
Costanzo, G. (IT)
Di Mauro, E. (IT)
Wunnava, S. (DE)
Braun, D. (DE)
Matyášek, Roman (BFU-R) ORCID
Kovařík, Aleš (BFU-R) RID, ORCIDNumber of authors 11 Source Title CHEMSYSTEMSCHEM. - : Wiley
Roč. 3, č. 6 (2021)Number of pages 10 s. Publication form Online - E Language eng - English Country US - United States Keywords long prebiotic oligomers ; origin ; oligonucleotides ; crystal ; life Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology R&D Projects GA19-03442S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BFU-R - RVO:68081707 UT WOS 000671941700001 DOI 10.1002/syst.202100017 Annotation Previous studies on the polymerization of 3',5' cyclic guanosine monophosphate (cGMP) demonstrated the potential of the compound in the abiotic generation of the first oligonucleotide sequences on the early Earth. These experiments were conducted under idealized laboratory conditions, which logically raises the question whether the same chemistry could take place in the harsh environment present on our planet in its earliest days. In the current study, we focus on the mineralogical context of this chemistry and show that numerous, but not all, common minerals assumed to be present on the early Earth could host the polymerization of H-form 3',5' cGMP. In particular, we have found that quartz varieties are especially suitable for this purpose, similar to andalusite, amphibole or micas. On the contrary, olivine, calcite, and serpentine-group minerals interfere with the studied polymerization chemistry. Our results show that crystallization on mineral surfaces, which is mainly a diffusion controlled process, determines the ability of 3',5' cGMP to polymerize. The observation that numerous amorphous and crystalline SiO2 forms are compatible with the oligomerization chemistry suggests that the process could commonly occur in a wide range of primordial environments allowing for crystallization of the cyclic monomers from a dropping solution. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2022 Electronic address https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/syst.202100017
Number of the records: 1