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Cyclodextrin-based transporter of nucleoside triphosphate transporter across the cell membrane, its preparation and use

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    0552741 - ÚOCHB 2022 RIV eng P - Patent Document
    Kraus, Tomáš - Zawada, Zbigniew
    Cyclodextrin-based transporter of nucleoside triphosphate transporter across the cell membrane, its preparation and use.
    2021. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. Date of the patent acceptance: 09.11.2021. Patent Number: US11168153
    R&D Projects: GA ČR(CZ) GA17-14791S
    Institutional support: RVO:61388963
    Keywords : transmembrane transport * anion transporters * DNA labelling
    OECD category: Organic chemistry
    https://worldwide.espacenet.com/patent/search/family/058410055/publication/US11168153B2?q=US11168153

    Compounds of general formulae 6 and 13 where X is —NH—C(NH2)═N+H2 or —N+H3, Y is a linear oligomer of arginine units terminated with an aminodimethylenamide unit (-Arg)n-NH—(CH2)2—NH2, where n=6-10, or arginine-aminocaproic units (-Arg-Aca)n-NH2, where n=6 to 10, A-═CF3COO— or Cl— and m=1-2. Preparation and use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membranes for the purpose of incorporation of modified nucleoside triphosphates into cellular DNA or RNA. Use of compounds of general formula 6 and 13 as carriers of nucleoside triphosphates across the cell membrane for determining the virostatic activities of modified nucleoside triphosphates. Use of compounds of general formula 6 and 13 as carriers of modified nucleoside triphosphates across the cell membrane for determining cell proliferation and S phase of the cell cycle.
    Permanent Link: http://hdl.handle.net/11104/0327857

     
     
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