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Acute pneumonia caused by clinically isolated Legionella pneumophila Sg 1, ST 62: host responses and pathologies in mice
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SYSNO ASEP 0551953 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acute pneumonia caused by clinically isolated Legionella pneumophila Sg 1, ST 62: host responses and pathologies in mice Author(s) Trousil, Jiří (UMCH-V) RID, ORCID
Frgelecová, L. (CZ)
Kubíčková, P. (CZ)
Řeháková, K. (CZ)
Drašar, V. (CZ)
Matějková, J. (CZ)
Štěpánek, Petr (UMCH-V) RID, ORCID
Pavliš, O. (CZ)Article number 179 Source Title Microorganisms. - : MDPI
Roč. 10, č. 1 (2022)Number of pages 15 s. Language eng - English Country CH - Switzerland Keywords legionellosis ; histopathology ; A/J mouse Subject RIV EE - Microbiology, Virology OECD category Microbiology Method of publishing Open access Institutional support UMCH-V - RVO:61389013 UT WOS 000757041100001 EID SCOPUS 85122884018 DOI 10.3390/microorganisms10010179 Annotation Legionnaires’ disease is a severe form of lung infection caused by bacteria belonging to the genus Legionella. The disease severity depends on both host immunity and L. pneumophila virulence. The objective of this study was to describe the pathological spectrum of acute pneumonia caused by a virulent clinical isolate of L. pneumophila serogroup 1, sequence type 62. In A/JOlaHsd mice, we compared two infectious doses, namely, 104 and 106 CFU, and their impact on the mouse status, bacterial clearance, lung pathology, and blood count parameters was studied. Acute pneumonia resembling Legionnaires’ disease has been described in detail. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://www.mdpi.com/2076-2607/10/1/179
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