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Encyclopedia of Biological Chemistry
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SYSNO ASEP 0551595 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Enzymes: HIV Protease Author(s) Majerová, T. (CZ)
Konvalinka, Jan (UOCHB-X) RID, ORCIDSource Title Encyclopedia of Biological Chemistry, 3. - Amsterdam : Elsevier, 2021 / Jez J. - ISBN 978-0-12-819460-7 Pages s. 264-269 Number of pages 6 s. Number of pages 785 Publication form Print - P Language eng - English Country NL - Netherlands Keywords AIDS ; autoprocessing ; drug design ; drug resistance ; enthalpy ; entropy ; Gag-Pol ; HIV-1 protease ; HIV-protease ; inhibitors ; precursor ; SARS-CoV2 OECD category Biochemistry and molecular biology Institutional support UOCHB-X - RVO:61388963 EID SCOPUS 85118525996 DOI 10.1016/B978-0-12-819460-7.00172-9 Annotation HIV protease is a dimeric aspartic protease that plays a key role in viral maturation. HIV polyproteins are cleaved by HIV protease into functional proteins during the process of maturation, which enables viral progeny to infect new host cells. The indispensable role of HIV protease in the viral life cycle makes it a suitable therapeutic target. Development of inhibitors of HIV protease heralded a new era in treatment of HIV–highly effective combinations of several antiretroviral drugs with different mechanisms of action–and advanced the development of other antiviral therapies. HIV protease is an extremely well-studied enzyme and a suitable model enzyme for various studies. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2022 Electronic address https://doi.org/10.1016/B978-0-12-819460-7.00172-9
Number of the records: 1