Number of the records: 1
Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl derivatives inspired by biological cubic membranes
- 1.
SYSNO ASEP 0551384 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Plasmalogen-based liquid crystalline multiphase structures involving docosapentaenoyl derivatives inspired by biological cubic membranes Author(s) Angelova, A. (FR)
Angelov, Borislav (FZU-D) ORCID
Drechsler, M. (DE)
Bizien, T. (FR)
Gorshkova, Yu. E. (RU)
Deng, Y. (CN)Number of authors 6 Article number 617984 Source Title Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 9, FEB (2021)Number of pages 22 s. Language eng - English Country CH - Switzerland Keywords docosapentaenoyl phospholipids ; lipid cubic phase ; inverted hexagonal phase ; plasmalogen-loaded cubosomes ; hexosomes ; SAXS ; cryo-TEM Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects EF15_003/0000447 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_019/0000789 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure ELI Beamlines III - 90141 - Fyzikální ústav AV ČR, v. v. i. Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000621375100001 EID SCOPUS 85101720702 DOI 10.3389/fcell.2021.617984 Annotation Structural properties of plasmenyl-glycerophospholipids (plasmalogens) have been scarcely studied for plasmalogens with long polyunsaturated fatty acid (PUFA) chains, despite of their significance for the organization and functions of the cellular membranes. Elaboration of supramolecular assemblies involving PUFA-chain plasmalogens in nanostructured mixtures with lyotropic lipids may accelerate the development of nanomedicines for certain severe pathologies (e.g., peroxisomal disorders, cardiometabolic impairments, and neurodegenerative Alzheimer's and Parkinson's diseases). Here, we investigate the spontaneous self-assembly of bioinspired, custom-produced docosapentaenoyl (DPA) plasmenyl (ether) and ester phospholipids in aqueous environment (pH 7) by synchrotron small-angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (cryo-TEM). Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2022 Electronic address http://hdl.handle.net/11104/0326800
Number of the records: 1