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On the Role of Arkypallidal and Prototypical Neurons for Phase Transitions in the External Pallidum
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SYSNO ASEP 0546897 Document Type J - Journal Article R&D Document Type The record was not marked in the RIV Subsidiary J Článek ve WOS Title On the Role of Arkypallidal and Prototypical Neurons for Phase Transitions in the External Pallidum Author(s) Gast, R. (DE)
Gong, R. (DE)
Schmidt, Helmut (UIVT-O) ORCID, RID, SAI
Meijer, G. (NL)
Knösche, T.R. (DE)Number of authors 5 Source Title Journal of Neuroscience. - : Society for Neuroscience - ISSN 0270-6474
Roč. 41, č. 31 (2021), s. 6673-6683Language eng - English Country US - United States Keywords globus-pallidus ; basal ganglia ; subthalamic nucleus ; parkinsons-disease ; beta oscillations ; response curve ; network ; spiking ; model ; synchronization ; basal ganglia ; neural network ; oscillations ; pallidum ; Parkinson ; phase-amplitude coupling UT WOS 000684594500008 EID SCOPUS 85112336022 DOI https://doi.org/10.1523/JNEUROSCI.0094-21.2021 Annotation The external pallidum (globus pallidus pars externa [GPe]) plays a central role for basal ganglia functions and dynamics and, consequently, has been included in most computational studies of the basal ganglia. These studies considered the GPe as a homogeneous neural population. However, experimental studies have shown that the GPe contains at least two distinct cell types (prototypical and arkypallidal cells). In this work, we provide in silico insight into how pallidal heterogeneity modulates dynamic regimes inside the GPe and how they affect the GPe response to oscillatory input. We derive a mean-field model of the GPe system from a microscopic spiking neural network of recurrently coupled prototypical and arkypallidal neurons. Using bifurcation analysis, we examine the influence of dopamine-dependent changes of intrapallidal connectivity on the GPe dynamics. We find that increased self-inhibition of prototypical cells can induce oscillations, whereas increased inhibition of prototypical cells by arkypallidal cells leads to the emergence of a bistable regime. Furthermore, we show that oscillatory input to the GPe, arriving from striatum, leads to characteristic patterns of cross-frequency coupling observed at the GPe. Based on these findings, we propose two different hypotheses of how dopamine depletion at the GPe may lead to phase-am-plitude coupling between the parkinsonian beta rhythm and a GPe-intrinsic gamma rhythm. Finally, we show that these findings generalize to realistic spiking neural networks of sparsely coupled Type I excitable GPe neurons. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2022
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