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Controlled anchoring of (phenylureido)sulfonamide-based receptor moieties: an impact of binding site multiplication on complexation properties
- 1.0545524 - ÚCHP 2022 RIV CH eng J - Journal Article
Salvadori, Karolína - Krupková, Alena - Červenková Šťastná, Lucie - Müllerová, Monika - Eigner, V. - Strašák, Tomáš - Cuřínová, Petra
Controlled anchoring of (phenylureido)sulfonamide-based receptor moieties: an impact of binding site multiplication on complexation properties.
Molecules. Roč. 26, č. 18 (2021), č. článku 5670. ISSN 1420-3049. E-ISSN 1420-3049
R&D Projects: GA ČR(CZ) GA20-07833S
Institutional support: RVO:67985858
Keywords : host-guest chemistry * dendrimers * supramolecular chemistry
OECD category: Organic chemistry
Impact factor: 4.927, year: 2021
Method of publishing: Open access
https://www.mdpi.com/1420-3049/26/18/5670
The repetition of urea-based binding units within the receptor structure does not only lead to monomer properties multiplication. As confirmed by spectroscopic studies, UV-Vis and 1H-NMR in classical or competitive titration mode, the attachment to a carrier allocates the active moieties to mutual positions predetermining the function of the whole receptor molecule. Bivalent receptors form self-aggregates. Dendritic receptors with low dihydrogen phosphate loadings offer a
cooperative complexation mode associated with a positive dendritic effect. In higher dihydrogen phosphate concentrations, the dendritic branches act independently and the binding mode changes to 1:1 anion: complexation site. Despite the anchoring, the dendritic receptors retain the superior efficiency and selectivity of a monomer, paving the way to recyclable receptors, desirable for economic and ecological reasons.
Permanent Link: http://hdl.handle.net/11104/0323701
File Download Size Commentary Version Access molecules-26-05670-v2.pdf 1 1.5 MB Publisher’s postprint open-access
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