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Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics.
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SYSNO ASEP 0544564 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics. Author(s) Horník, Štěpán (UCHP-M) ORCID, RID, SAI
Michálková, Lenka (UCHP-M) RID, ORCID, SAI
Sýkora, Jan (UCHP-M) RID, ORCID, SAI
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Vlčková, Š. (CZ)
Dvořáčková, Š. (CZ)
Pelclová, D. (CZ)Article number 6601 Source Title Applied Sciences-Basel. - : MDPI
Roč. 11, č. 4 (2021)Number of pages 18 s. Language eng - English Country CH - Switzerland Keywords exhaled breath condensate ; human plasma ; nanoparticles exposure ; NMR metabolomics Subject RIV DN - Health Impact of the Environment Quality OECD category Environmental sciences (social aspects to be 5.7) R&D Projects LM2018122 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) TK02010035 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Method of publishing Open access Institutional support UCHP-M - RVO:67985858 UT WOS 000675931400001 EID SCOPUS 85111257168 DOI 10.3390/app11146601 Annotation In this study, the effects of occupational exposure to nanoparticles (NPs) were studied by NMR metabolomics. Exhaled breath condensate (EBC) and blood plasma samples were obtained from a research nanoparticles-processing unit at a national research university. The samples were taken from three groups of subjects: samples from workers exposed to nanoparticles collected before and after shift, and from controls not exposed to NPs. Altogether, 601H NMR spectra of exhaled breath condensate (EBC) samples and 601H NMR spectra of blood plasma samples were analysed, 20 in each group. The metabolites identified together with binning data were subjected to multivariate statistical analysis, which provided clear discrimination of the groups studied. Statistically sig-nificant metabolites responsible for group separation served as a foundation for analysis of im-paired metabolic pathways. It was found that the acute effect of NPs exposure is mainly reflected in the pathways related to the production of antioxidants and other protective species, while the chronic effect is manifested mainly in the alteration of glutamine and glutamate metabolism, and the purine metabolism pathway. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2022 Electronic address https://www.mdpi.com/2076-3417/11/14/6601
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