Number of the records: 1  

Pattern recognition receptors in annelids

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    SYSNO ASEP0540856
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitlePattern recognition receptors in annelids
    Author(s) Procházková, Petra (MBU-M) RID, ORCID
    Roubalová, Radka (MBU-M) RID, ORCID
    Dvořák, Jiří (MBU-M) RID, ORCID
    Navarro Pacheco, Natividad Isabel (MBU-M) ORCID
    Bilej, Martin (MBU-M) RID, ORCID
    Article numberUNSP 103493
    Source TitleDevelopmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
    Roč. 102, JAN 2020 (2020)
    Number of pages8 s.
    Languageeng - English
    CountryGB - United Kingdom
    KeywordsEarthworm ; Annelida ; Phenoloxidase cascade
    Subject RIVEC - Immunology
    OECD categoryImmunology
    Method of publishingOpen access
    Institutional supportMBU-M - RVO:61388971
    UT WOS000491213900021
    EID SCOPUS85071929721
    DOI https://doi.org/10.1016/j.dci.2019.103493
    AnnotationThe existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of various proinflammatory molecules. These recognition molecules represent an important and efficient innate immunity tool of all organisms. As invertebrates lack the instruments of the adaptive immune system, based on
    ´true´ lymphocytes and functional antibodies, the importance of PRRs are even more fundamental. In the present review, the structure, specificity, and expression profiles of PRRs characterized in annelids are discussed, and their role in innate defense is suggested.
    WorkplaceInstitute of Microbiology
    ContactEliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
    Year of Publishing2021
    Electronic addresshttps://www.sciencedirect.com/science/article/pii/S0145305X1930312X?via%3Dihub
Number of the records: 1  

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