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Pattern recognition receptors in annelids
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SYSNO ASEP 0540856 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pattern recognition receptors in annelids Author(s) Procházková, Petra (MBU-M) RID, ORCID
Roubalová, Radka (MBU-M) RID, ORCID
Dvořák, Jiří (MBU-M) RID, ORCID
Navarro Pacheco, Natividad Isabel (MBU-M) ORCID
Bilej, Martin (MBU-M) RID, ORCIDArticle number UNSP 103493 Source Title Developmental and Comparative Immunology. - : Elsevier - ISSN 0145-305X
Roč. 102, JAN 2020 (2020)Number of pages 8 s. Language eng - English Country GB - United Kingdom Keywords Earthworm ; Annelida ; Phenoloxidase cascade Subject RIV EC - Immunology OECD category Immunology Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000491213900021 EID SCOPUS 85071929721 DOI https://doi.org/10.1016/j.dci.2019.103493 Annotation The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of various proinflammatory molecules. These recognition molecules represent an important and efficient innate immunity tool of all organisms. As invertebrates lack the instruments of the adaptive immune system, based on
´true´ lymphocytes and functional antibodies, the importance of PRRs are even more fundamental. In the present review, the structure, specificity, and expression profiles of PRRs characterized in annelids are discussed, and their role in innate defense is suggested.Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0145305X1930312X?via%3Dihub
Number of the records: 1