Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential

0539303 - ÚEB 2021 RIV CH eng J - Journal Article
Nahar, Lutfun - Talukdar, A. D. - Nath, D. - Nath, S. - Mehan, A. - Ismail, F. M.D. - Sarker, S. D.
Naturally Occurring Calanolides: Occurrence, Biosynthesis, and Pharmacological Properties Including Therapeutic Potential.
Molecules. Roč. 25, č. 21 (2020), č. článku 4983. E-ISSN 1420-3049
Institutional support: RVO:61389030
Keywords : anti-HIV * calanolide A * calanolides * Calophyllaceae * Calophyllum * non-nucleoside reverse transcriptase inhibitors (NNRTIs) * pseudocalanolides * reverse transcriptase
OECD category: Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)
Impact factor: 4.412, year: 2020
Method of publishing: Open access
http://doi.org/10.3390/molecules25214983

Calanolides are tetracyclic 4-substituted dipyranocoumarins. Calanolide A, isolated from the leaves and twigs of Calophyllum lanigerum var. austrocoriaceum (Whitmore) P. F. Stevens, is the first member of this group of compounds with anti-HIV-1 activity mediated by reverse transcriptase inhibition. Calanolides are classified pharmacologically as non-nucleoside reverse transcriptase inhibitors (NNRTI). There are at least 15 naturally occurring calanolides distributed mainly within the genus Calophyllum, but some of them are also present in the genus Clausena. Besides significant anti-HIV properties, which have been exploited towards potential development of new NNRTIs for anti-HIV therapy, calanolides have also been found to possess anticancer, antimicrobial and antiparasitic potential. This review article provides a comprehensive update on all aspects of naturally occurring calanolides, including their chemistry, natural occurrence, biosynthesis, pharmacological and toxicological aspects including mechanism of action and structure activity relationships, pharmacokinetics, therapeutic potentials and available patents.
Permanent Link: http://hdl.handle.net/11104/0316993