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Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities
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SYSNO ASEP 0538469 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Perinatal Hypoxic-Ischemic Damage: Review of the Current Treatment Possibilities Author(s) Frajewicki, A. (CZ)
Laštůvka, Z. (CZ)
Borbélyová, V. (SK)
Khan, S. (CZ)
Jandová, K. (CZ)
Janišová, K. (CZ)
Otáhal, Jakub (FGU-C) RID, ORCID, SAI
Mysliveček, J. (CZ)
Riljak, V. (CZ)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 69, Suppl.3 (2020), S379-S401Number of pages 23 s. Language eng - English Country CZ - Czech Republic Keywords hypoxia ; hypoxic-ischemic encephalopathy ; immature brain ; treatment Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000610191500004 EID SCOPUS 85100228214 DOI 10.33549/physiolres.934595 Annotation Neonatal hypoxic-ischemic encephalopathy is a disorder with heterogeneous manifestation due to asphyxia during perinatal period. It affects approximately 3-12 children per 1000 live births and cause death of 1 million neonates worldwide per year. Besides, motor disabilities, seizures, impaired muscle tone and epilepsy are few of the consequences of hypoxic-ischemic encephalopathy. Despite an extensive research effort regarding various treatment strategies, therapeutic hypothermia with intensive care unit supportive treatment remains the only approved method for neonates who have suffered from moderate to severe hypoxicischemic encephalopathy. However, these protocols are only partially effective given that many infants still suffer from severe brain damage. Thus, further research to systematically test promising neuroprotective treatments in combination with hypothermia is essential. In this review, we discussed the pathophysiology of hypoxic-ischemic encephalopathy and delved into different promising treatment modalities, such as melatonin and erythropoietin. However, preclinical studies and clinical trials are still needed to further elucidate the mechanisms of action of these modalities. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address http://www.biomed.cas.cz/physiolres/pdf/2020/69_S379.pdf
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