A novel Cu(II) distorted cubane complex containing Cu.sub.4./sub.O.sub.4./sub. core as the first tetranuclear catalyst for temperature dependent oxidation of 3,5-di-tert-butyl catechol and in interaction with DNA & protein (BSA)

0537821 - FZÚ 2021 RIV GB eng J - Journal Article
Asadi, Z. - Zarei, L. - Golchin, M. - Skořepová, Eliška - Eigner, Václav - Amirghofran, Z.
A novel Cu(II) distorted cubane complex containing Cu₄O₄ core as the first tetranuclear catalyst for temperature dependent oxidation of 3,5-di-tert-butyl catechol and in interaction with DNA & protein (BSA).
Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy. Roč. 227, Feb (2020), s. 1-15, č. článku 117593. ISSN 1386-1425. E-ISSN 1873-3557
R&D Projects: GA MŠMT(CZ) LO1603; GA ČR(CZ) GA18-10504S
EU Projects: European Commission(CZ) CZ.2.16/3.1.00/24510
Institutional support: RVO:68378271
Keywords : Cu(II) cubane complex * catecholase activity * FS-DNA * BSA * docking study * anticancer activity
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 4.098, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.saa.2019.117593

The tri-dentate Schiff base ligand 3-(2-hydroxyethylimino)-1-phenylbut-1-en-1-ol produced the tetra-nuclear Cu(II) distorted cubane complex which contain Cu4O4 core, upon reaction with Cu(II)acetate. The complex was structurally characterized by X-ray crystallography. The kinetics and mechanism of the oxidation of 3, 5-DTBCH2 catalyzed by [CuL]4 complex, were studied at four different temperatures from 283 to 313K by UV-Vis spectroscopy. The main mode of binding of the complexes with DNA was intercalation. The interaction between [CuL]4 complex and bovine serum albumin (BSA) was studied by UV-Vis, fluorescence and synchronous fluorescence spectroscopic techniques. Theoretical docking studies were performed to further investigate the DNA and BSA binding interactions.
Permanent Link: http://hdl.handle.net/11104/0315656