Translational Research in Serious Human Diseases

0536484 - ÚŽFG 2021 RIV CZ eng M - Monography Chapter
Klíma, Jiří
Huntington´s disease modeling in animals.
Translational Research in Serious Human Diseases. Praha: Academia, 2020 - (Kello, M.; Strnadel, J.; Klempir, J.; Roth, J.; Myslivcová-Fučíková, A.; Hansíková, H.; Kozák, I.), s. 20-29. ISBN 978-80-200-3158-7
R&D Projects: GA MŠMT(CZ) LO1609
Institutional support: RVO:67985904
Keywords : Huntington´s disease * animal model * mutant huntingtin
OECD category: Cell biology

Animal models are valuable tools in the determination of expression and physiologic function of studied genes. Huntington's disease as monogenic autosomal disorder is still enigmatic in mechanism by which mutant gene expression affects molecular, physiological, and neurological functions in patients. Recently many animal genetic models were established in an effort to determine and understand changes in tissues and organs leading to disease onset, its progression and manifestation.
Permanent Link: http://hdl.handle.net/11104/0314256