Number of the records: 1
Mitochondrial complex II and reactive oxygen species in disease and therapy
- 1.
SYSNO ASEP 0535930 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondrial complex II and reactive oxygen species in disease and therapy Author(s) Váňová Hadrava, Kateřina (BTO-N)
Kraus, Michal (BTO-N)
Neužil, Jiří (BTO-N) RID, ORCID
Rohlena, Jakub (BTO-N) RID, ORCIDNumber of authors 4 Source Title Redox Report. - : Taylor & Francis - ISSN 1351-0002
Roč. 25, č. 1 (2020), s. 26-32Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords Respiratory complex II ; succinate dehydrogenase ; reactive oxygen species Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects GA19-20553S GA ČR - Czech Science Foundation (CSF) GA20-18513S GA ČR - Czech Science Foundation (CSF) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BTO-N - RVO:86652036 UT WOS 000526433700001 EID SCOPUS 85083407813 DOI https://doi.org/10.1080/13510002.2020.1752002 Annotation Increasing evidence points to the respiratory Complex II (CII) as a source and modulator of reactive oxygen species (ROS). Both functional loss of CII as well as its pharmacological inhibition can lead to ROS generation in cells, with a relevant impact on the development of pathophysiological conditions, i.e. cancer and neurodegenerative diseases. While the basic framework of CII involvement in ROS production has been defined, the fine details still await clarification. It is important to resolve these aspects to fully understand the role of CII in pathology and to explore its therapeutic potential in cancer and other diseases. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2021 Electronic address https://www.tandfonline.com/doi/pdf/10.1080/13510002.2020.1752002?needAccess=true&
Number of the records: 1