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Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats
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SYSNO ASEP 0535840 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats Author(s) Mareš, Pavel (FGU-C) RID, ORCID
Kudová, Eva (UOCHB-X) RID, ORCID
Valeš, Karel (FGU-C) RID, ORCID, SAI
Kubová, Hana (FGU-C) RID, ORCIDSource Title Pharmacological Reports. - : Springer - ISSN 1734-1140
Roč. 72, č. 6 (2020), s. 1573-1578Number of pages 6 s. Language eng - English Country PL - Poland Keywords cortical afterdischarges ; postical potentiation ; immature rats ; neurosteroids ; gabaergic drugs Subject RIV FH - Neurology OECD category Neurosciences (including psychophysiology Subject RIV - cooperation Institute of Organic Chemistry and Biochemistry - Neurology R&D Projects GA18-09296S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 ; UOCHB-X - RVO:61388963 UT WOS 000539580800001 EID SCOPUS 85086101460 DOI 10.1007/s43440-020-00113-2 Annotation Background:Postictal potentiation presented immediately after cortical seizures in immature rats might be due to imbalance between excitation and inhibition. The aim of the present study was to determine whether augmentation of inhibition mediated by GABAA receptors could also suppress the postictal potentiation.Methods:Twelve-day old rats with implanted electrodes were used in our study. Five drugs were tested: the agonist muscimol, the positive modulator midazolam and three neurosteroids affecting GABAA receptors—allopregnanolone, pregnanolone sulphate and pregnanolone glutamate.Results:None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures.Conclusion:Our results support a role of GABA in augmentation of cortical after discharges after longer intervals, whereas immediate postictal potentiation is not affected by GABAergic drugs. Due to similar effect with GABAergic drugs, the main mechanism of action of the three steroids tested is potentiation of GABAergic inhibition. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://doi.org/10.1007/s43440-020-00113-2
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