Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years.

Pelclová, D.; Ždímal, Vladimír; Komarc, M.; Schwarz, Jaroslav; Ondráček, Jakub; Ondráčková, Lucie; Koštejn, Martin; Vlčková, Š.; Fenclová, Z.; Dvořáčková, Š.; Lischová, L.; Klusáčková, P.; Klesnikova, V.; Rössnerová, Andrea; Navrátil, Tomáš

doi:https://dx.doi.org/10.3390/nano10122440

Number of the records: 1

Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years.

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SYSNO ASEP	0535687
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites, Extended by Plasma and Urine Analysis in Last Two Years.
Author(s)	Pelclová, D. (CZ) Ždímal, Vladimír (UCHP-M)_{RID, ORCID, SAI} Komarc, M. (CZ) Schwarz, Jaroslav (UCHP-M)_{RID, ORCID, SAI} Ondráček, Jakub (UCHP-M)_{RID, ORCID, SAI} Ondráčková, Lucie (UCHP-M)_{RID, ORCID, SAI} Koštejn, Martin (UCHP-M)_{RID, SAI, ORCID} Vlčková, Š. (CZ) Fenclová, Z. (CZ) Dvořáčková, Š. (CZ) Lischová, L. (CZ) Klusáčková, P. (CZ) Klesnikova, V. (CZ) Rössnerová, Andrea (UEM-P)_RID Navrátil, Tomáš (UFCH-W)_{RID, ORCID}
Article number	2440
Source Title	Nanomaterials. - : MDPI Roč. 10, č. 12 (2020)
Number of pages	25 s.
Language	eng - English
Country	CH - Switzerland
Keywords	nanoparticles ; oxidative stress ; biomarkers ; workers ; controls
Subject RIV	DN - Health Impact of the Environment Quality
OECD category	Public and environmental health
Subject RIV - cooperation	Institute of Experimental Medicine - Health Impact of the Environment Quality J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry
R&D Projects	GA18-02079S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	UCHP-M - RVO:67985858 ; UEM-P - RVO:68378041 ; UFCH-W - RVO:61388955
UT WOS	000602622000001
EID SCOPUS	85097542423
DOI	10.3390/nano10122440
Annotation	Human data concerning exposure to nanoparticles are very limited, and biomarkers for monitoring exposure are urgently needed. In a follow-up of a 2016 study in a nanocomposites plant, in which only exhaled breath condensate (EBC) was examined, eight markers of oxidative stress were analyzed in three bodily fluids, i.e., EBC, plasma and urine, in both pre-shift and post-shift samples in 2017 and 2018. Aerosol exposures were monitored. Mass concentration in 2017 was 0.351 mg/m3 during machining, and 0.179 and 0.217 mg/m3 during machining and welding, respectively, in 2018. In number concentrations, nanoparticles formed 96%, 90% and 59%, respectively. In both years, pre-shift elevations of 50.0% in EBC, 37.5% in plasma and 6.25% in urine biomarkers were observed. Post-shift elevation reached 62.5% in EBC, 68.8% in plasma and 18.8% in urine samples. The same trend was observed in all biological fluids. Individual factors were responsible for the elevation of control subjects’ afternoon vs. morning markers in 2018, all were significantly lower compared to those of workers. Malondialdehyde levels were always acutely shifted, and 8-hydroxy-2-deoxyguanosine levels best showed chronic exposure effect. EBC and plasma analysis appear to be the ideal fluids for bio-monitoring of oxidative stress arising from engineered nanomaterials. Potential late effects need to be targeted and prevented, as there is a similarity of EBC findings in patients with silicosis and asbestosis.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2021
Electronic address	https://www.mdpi.com/2079-4991/10/12/2440/pdf

Number of the records: 1