Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation

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SYSNO ASEP	0535242
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation
Author(s)	Ahmad, Jawid Nazir (MBU-M)_RID Šebo, Peter (MBU-M)_{RID, ORCID}
Article number	2181
Source Title	Frontiers in Immunology. - : Frontiers Media - ISSN 1664-3224 Roč. 11, SEP 11 2020 (2020)
Number of pages	7 s.
Language	eng - English
Country	CH - Switzerland
Keywords	dedifferentiation ; Bordetella pertussis ; adenylate cyclase toxin
Subject RIV	EC - Immunology
OECD category	Immunology
R&D Projects	GX19-27630X GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	MBU-M - RVO:61388971
UT WOS	000576010100001
EID SCOPUS	85091588111
DOI	10.3389/fimmu.2020.02181
Annotation	Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity ofBordetella pertussisadenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2021
Electronic address	https://www.frontiersin.org/articles/10.3389/fimmu.2020.02181/full

Number of the records: 1