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Pharmacological activities of sesquiterpene lactone trilobolide and its conjugates as promising compounds for anticancer and immunomodulatory therapies
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SYSNO ASEP 0534702 Document Type A - Abstract R&D Document Type The record was not marked in the RIV R&D Document Type Není vybrán druh dokumentu Title Pharmacological activities of sesquiterpene lactone trilobolide and its conjugates as promising compounds for anticancer and immunomodulatory therapies Author(s) Kmoníčková, Eva (UEM-P) RID
Rimpelová, S. (CZ)
Jurášek, M. (CZ)
Džubák, P. (CZ)
Sedlák, D. (CZ)
Zídek, Zdeněk (UEM-P)
Harmatha, Juraj (UOCHB-X) RID, ORCID
Drašar, P. (CZ)Source Title Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018. - Tokyo : Japanese Pharmacological Society, 2018
„OR34-3“Number of pages 1 s. Publication form Print - P Action World Congress of Basic and Clinical Pharmacology /18./ Event date 01.07.2018 - 06.07.2018 VEvent location Kyoto Country JP - Japan Event type WRD Language eng - English Country JP - Japan Keywords SERCA inhibitor ; cancer ; cytokines Subject RIV FR - Pharmacology ; Medidal Chemistry OECD category Medicinal chemistry Institutional support UOCHB-X - RVO:61388963 DOI 10.1254/jpssuppl.WCP2018.0_OR34-3 Annotation Trilobolide and its conjugates exhibited sufficient intracellular accumulation and specific localization. Cytotoxic effects were observed in submicromolar concentrations in some drug-resistant cancer cell lines. Trilobolide is less toxic for fibroblasts and macrophages. Specific immunostimulatory effect (NO production, IFN-gamma, IL-2 secretion) of trilobolides is dose- and structure-dependent. Trilobolide-porphyrin conjugates with low toxicity, represent an interesting tool for photodynamic therapy. In summary, trilobolide and its conjugates could be a useful tool in anti-cancer, anti-infectious and immunomodulatory therapies. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2021
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