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Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
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SYSNO ASEP 0534516 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Neutron Activated Sm-153 Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy Author(s) Wang, J. T. W. (GB)
Klippstein, R. (ES)
Martincic, M. (ES)
Pach, E. (ES)
Feldman, R. (FR)
Šefl, M. (CZ)
Michel, Y. (FR)
Asker, D. (GB)
Sosabowski, J. K. (GB)
Kalbáč, Martin (UFCH-W) RID, ORCID
Da Ros, T. (IT)
Menard-Moyon, C. (FR)
Bianco, A. (IT)
Kyriakou, I. (GR)
Emfietzoglou, D. (GR)
Saccavini, J.-C. (FR)
Ballesteros, B. (ES)
Al-Jamal, K. T. (GB)
Tobias, G. (ES)Source Title ACS Nano. - : American Chemical Society - ISSN 1936-0851
Roč. 14, č. 1 (2020), s. 129-141Number of pages 13 s. Language eng - English Country US - United States Keywords mesoporous silica nanoparticles ; holmium nanoparticles ; nanotubes ; encapsulation ; vitro ; metastases ; strategies ; samarium ; behavior ; biology ; cancer therapy ; nuclear imaging ; nanoencapsulation ; filled carbon nanotubes ; radiooncology ; nanooncology Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects LTC18039 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_013/0001821 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access with time embargo (01.12.2020) Institutional support UFCH-W - RVO:61388955 UT WOS 000510531500008 EID SCOPUS 85076733884 DOI 10.1021/acsnano.9b04898 Annotation Radiation therapy along with chemotherapy and surgery remain the main cancer treatments. Radiotherapy can be applied to patients externally (external beam radiotherapy) or internally (brachytherapy and radioisotope therapy). Previously, nanoencapsulation of radioactive crystals within carbon nano-tubes, followed by end-closing, resulted in the formation of nanocapsules that allowed ultrasensitive imaging in healthy mice. Herein we report on the preparation of nanocapsules initially sealing ´cold´ isotopically enriched samarium (Sm-152), which can then be activated on demand to their ´hot´ radioactive form (Sm-153) by neutron irradiation. The use of ´cold´ isotopes avoids the need for radioactive facilities during the preparation of the nanocapsules, reduces radiation exposure to personnel, prevents the generation of nuclear waste, and evades the time constraints imposed by the decay of radionuclides. A very high specific radioactivity is achieved by neutron irradiation (up to 11.37 GBq/mg), making the ´hot´ nanocapsules useful not only for in vivo imaging but also therapeutically effective against lung cancer metastases after intravenous injection. The high in vivo stability of the radioactive payload, selective toxicity to cancerous tissues, and the elegant preparation method offer a paradigm for application of nanomaterials in radiotherapy. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0312700
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