0534082 - ÚBO 2021 RIV GB eng J - Journal Article
Cuypers, L. N. - Baird, Stuart J. E. - Hánová, Alexandra - Locus, T. - Katakweba, A. S. - Gryseels, S. - Bryja, Josef - Leirs, H. - Goüy de Bellocq, Joëlle
Three arenaviruses in three subspecific natal multimammate mouse taxa in Tanzania: same host specificity, but different spatial genetic structure?
Virus Evolution. Roč. 6, č. 2 (2020), č. článku veaa039. E-ISSN 2057-1577
R&D Projects: GA ČR GA15-20229S; GA ČR(CZ) GA18-19629S
Institutional support: RVO:68081766
Keywords : arenavirus host specificity * regional prevalence differences * spatial genetic structure * Gairo mammarenavirus * Morogoro mammarenavirus * Luna mammarenavirus
OECD category: Virology
Impact factor: 7.989, year: 2020
Method of publishing: Open access
https://academic.oup.com/ve/article/6/2/veaa039/5840739

Mastomys natalensis is widespread in sub-Saharan Africa and hosts several arenavirus species, including the pathogenic zoonotic Lassa virus in West Africa. Mitochondrial lineages sub-divide the range of M. natalensis and have been associated with cryptic structure within the species. To test specificity of arenaviruses to hosts carrying these lineages, we screened 1772 M. natalensis in a large area of Tanzania where three mitochondrial lineages meet. We detected fifty-two individuals that were positive for one of three arenaviruses: Gairo, Morogoro, and Luna virus. This is the first record of Luna virus in Tanzania. We confirmed the specificity of each arenavirus to a distinct host mitochondrial lineage except for three cases in one locality at the centre of a host hybrid zone. No arenaviruses were detected in a large part of the study area. Morogoro and Gairo virus showed differences in prevalence (Morogoro virus lower than Gairo virus) and in genetic structure (Morogoro virus more structured than Gairo virus). However, both viruses have genetic neighbourhood size estimates of the same order of magnitude as Lassa virus. While differences in arenavirus and/or host evolutionary and ecological dynamics may exist, Tanzanian arenaviruses could be suited to model Lassa virus dynamics in M. natalensis.
Permanent Link: http://hdl.handle.net/11104/0312302