Regulation of cell death by mitochondrial transport systems of calcium and BCL‐2 proteins

0533843 - ÚFCH JH 2021 RIV CH eng J - Journal Article
Naumova, Natalia - Šachl, Radek
Regulation of cell death by mitochondrial transport systems of calcium and BCL‐2 proteins.
Membranes. Roč. 10, č. 10 (2020), č. článku 299. E-ISSN 2077-0375
R&D Projects: GA ČR(CZ) GA18-04871S
Institutional support: RVO:61388955
Keywords : Apoptosis * Bax * Bcl‐2 proteins * Calcium transport * mcu * Mitochondria * mptp * Necrosis * vdac
OECD category: Physical chemistry
Impact factor: 4.106, year: 2020
Method of publishing: Open access

Mitochondria represent the fundamental system for cellular energy metabolism, by not only supplying energy in the form of ATP, but also by affecting physiology and cell death via the regulation of calcium homeostasis and the activity of Bcl‐2 proteins. A lot of research has recently been devoted to understanding the interplay between Bcl‐2 proteins, the regulation of these interactions within the cell, and how these interactions lead to the changes in calcium homeostasis. However, the role of Bcl‐2 proteins in the mediation of mitochondrial calcium homeostasis, and therefore the induction of cell death pathways, remain underestimated and are still not well understood. In this review, we first summarize our knowledge about calcium transport systems in mitochondria, which, when miss‐regulated, can induce necrosis. We continue by reviewing and analyzing the functions of Bcl‐2 proteins in apoptosis. Finally, we link these two regulatory mechanisms together, exploring the interactions between the mitochondrial Ca2+ transport systems and Bcl‐2 proteins, both capable of inducing cell death, with the potential to determine the cell death pathway—either the apoptotic or the necrotic one.
Permanent Link: http://hdl.handle.net/11104/0312095