Number of the records: 1
Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties
- 1.
SYSNO ASEP 0532310 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties Author(s) Kubát, Pavel (UFCH-W) RID, ORCID, SAI
Henke, P. (CZ)
Raya, R.K. (CZ)
Štěpánek, M. (CZ)
Mosinger, Jiří (UACH-T) RID, ORCID, SAISource Title Langmuir. - : American Chemical Society - ISSN 0743-7463
Roč. 36, č. 1 (2020), s. 302-310Number of pages 9 s. Language eng - English Country US - United States Keywords singlet oxygen ; photodynamic therapy ; polymeric nanoparticles ; nanofiber materials ; protein corona ; temperature ; photosensitizers ; delivery ; nanofabrics ; particles Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Subject RIV - cooperation Institute of Inorganic Chemistry - Inorganic Chemistry R&D Projects GA19-09721S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access with time embargo (01.01.2021) Institutional support UFCH-W - RVO:61388955 ; UACH-T - RVO:61388980 UT WOS 000507721200034 EID SCOPUS 85077697578 DOI 10.1021/acs.langmuir.9b03468 Annotation The transport of a photosensitizer to target biological structures followed by the release of singlet oxygen is a critical step in photodynamic therapy. We compared the (photo)physical properties of polystyrene nanoparticles (TPP@PS) of different sizes and self-assembled poly(ethylene glycol)-b-poly(epsilon-caprolactone) core/shell nanoparticles (TPP@PEG-PCL) with different lengths of copolymer blocks, both suitable for the transport of the tetraphenylporphyrin (TPP) photosensitizer. The singlet oxygen was formed inside both nanoparticles after irradiation with visible light. Its kinetics was controlled by the size of TPP@PS, its lifetime (tau(Delta)) increased with increasing nanoparticle size (from 6.5 to 16 mu s) because of hindered diffusion into the external aqueous environment, where it was quickly deactivated. Accordingly, the prolongation of the singlet oxygen-sensitized delayed fluorescence kinetics was found for TPP@PS of high size. The TPP@PEG-PCL self-assemblies allowed for enhanced oxygen diffusion, and the estimated low values of tau(Delta) approximate to 3.7 mu s were independent of the size of building blocks. The delayed fluorescence in oxygen-free conditions originating from triplet-triplet annihilation indicated a high mobility of TPP in the PCL core in comparison with fixed molecules in the PS matrix. Photooxidation of uric acid revealed the highest efficacy for TPP@PS of small sizes, whereas the largest TPP@PS exhibited the lowest activity, and the efficacy of TPP@PEG-PCL remained independent of the sizes of the building blocks. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0310832
Number of the records: 1