Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties

Kubát, Pavel; Henke, P.; Raya, R.K.; Štěpánek, M.; Mosinger, Jiří

doi:https://dx.doi.org/10.1021/acs.langmuir.9b03468

Number of the records: 1

Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties

1.

SYSNO ASEP	0532310
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties
Author(s)	Kubát, Pavel (UFCH-W)_{RID, ORCID, SAI} Henke, P. (CZ) Raya, R.K. (CZ) Štěpánek, M. (CZ) Mosinger, Jiří (UACH-T)_{RID, ORCID, SAI}
Source Title	Langmuir : the ACS journal of surfaces and colloids - ISSN 0743-7463 Roč. 36, č. 1 (2020), s. 302-310
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	singlet oxygen ; photodynamic therapy ; polymeric nanoparticles ; nanofiber materials ; protein corona ; temperature ; photosensitizers ; delivery ; nanofabrics ; particles
Subject RIV	CF - Physical ; Theoretical Chemistry
OECD category	Physical chemistry
Subject RIV - cooperation	Institute of Inorganic Chemistry - Inorganic Chemistry
R&D Projects	GA19-09721S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access with time embargo (01.01.2021)
Institutional support	UFCH-W - RVO:61388955 ; UACH-T - RVO:61388980
UT WOS	000507721200034
EID SCOPUS	85077697578
DOI	https://doi.org/10.1021/acs.langmuir.9b03468
Annotation	The transport of a photosensitizer to target biological structures followed by the release of singlet oxygen is a critical step in photodynamic therapy. We compared the (photo)physical properties of polystyrene nanoparticles (TPP@PS) of different sizes and self-assembled poly(ethylene glycol)-b-poly(epsilon-caprolactone) core/shell nanoparticles (TPP@PEG-PCL) with different lengths of copolymer blocks, both suitable for the transport of the tetraphenylporphyrin (TPP) photosensitizer. The singlet oxygen was formed inside both nanoparticles after irradiation with visible light. Its kinetics was controlled by the size of TPP@PS, its lifetime (tau(Delta)) increased with increasing nanoparticle size (from 6.5 to 16 mu s) because of hindered diffusion into the external aqueous environment, where it was quickly deactivated. Accordingly, the prolongation of the singlet oxygen-sensitized delayed fluorescence kinetics was found for TPP@PS of high size. The TPP@PEG-PCL self-assemblies allowed for enhanced oxygen diffusion, and the estimated low values of tau(Delta) approximate to 3.7 mu s were independent of the size of building blocks. The delayed fluorescence in oxygen-free conditions originating from triplet-triplet annihilation indicated a high mobility of TPP in the PCL core in comparison with fixed molecules in the PS matrix. Photooxidation of uric acid revealed the highest efficacy for TPP@PS of small sizes, whereas the largest TPP@PS exhibited the lowest activity, and the efficacy of TPP@PEG-PCL remained independent of the sizes of the building blocks.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2021
Electronic address	http://hdl.handle.net/11104/0310832

Number of the records: 1