Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

Kroupová, Petra; van Schothorst, E. M.; Keijer, J.; Bunschoten, A.; Vodička, Martin; Irodenko, Ilaria; Oseeva, Marina; Žáček, P.; Kopecký, Jan; Rossmeisl, Martin; Horáková, Olga

doi:https://dx.doi.org/10.3390/nu12072037

Number of the records: 1

Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice

1.

SYSNO ASEP	0532017
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice
Author(s)	Kroupová, Petra (FGU-C)_ORCID van Schothorst, E. M. (NL) Keijer, J. (NL) Bunschoten, A. (NL) Vodička, Martin (FGU-C)_{RID, ORCID, SAI} Irodenko, Ilaria (FGU-C)_RID Oseeva, Marina (FGU-C)_{ORCID, RID} Žáček, P. (CZ) Kopecký, Jan (FGU-C)_{RID, ORCID} Rossmeisl, Martin (FGU-C)_{RID, ORCID} Horáková, Olga (FGU-C)_{RID, ORCID}
Article number	2037
Source Title	Nutrients. - : MDPI - ISSN 2072-6643 Roč. 12, č. 7 (2020)
Number of pages	20 s.
Language	eng - English
Country	CH - Switzerland
Keywords	krill oil ; Omega-3 phospholipids ; high-fat diet ; Omega-3 index ; small intestine
Subject RIV	FB - Endocrinology, Diabetology, Metabolism, Nutrition
OECD category	Endocrinology and metabolism (including diabetes, hormones)
R&D Projects	GA16-08124S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	FGU-C - RVO:67985823
UT WOS	000556892600001
EID SCOPUS	85087630620
DOI	https://doi.org/10.3390/nu12072037
Annotation	Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects could reflect changes in intestinal metabolism is unknown. Here, we compare Omega-3-containing phospholipids (krill oil, omega 3PL-H) and triacylglycerols (omega 3TG) in terms of their effects on morphology, gene expression and fatty acid (FA) oxidation in the small intestine. Male C57BL/6N mice were fed for 8 weeks with a high-fat diet (HFD) alone or supplemented with 30 mg/g diet of omega 3TG or omega 3PL-H. Omega-3 index, reflecting the bioavailability of Omega-3, reached 12.5% and 7.5% in the omega 3PL-H and omega 3TG groups, respectively. Compared to HFD mice, omega 3PL-H but not omega 3TG animals had lower body weight gain (-40%), mesenteric adipose tissue (-43%), and hepatic lipid content (-64%). The highest number and expression level of regulated intestinal genes was observed in omega 3PL-H mice. The expression of FA omega-oxidation genes was enhanced in both Omega-3-supplemented groups, but gene expression within the FA beta-oxidation pathway and functional palmitate oxidation in the proximal ileum was significantly increased only in omega 3PL-H mice. In conclusion, enhanced intestinal FA oxidation could contribute to the strong antisteatotic effects of Omega-3 when administered as phospholipids to dietary obese mice.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2021
Electronic address	https://www.mdpi.com/2072-6643/12/7/2037

Number of the records: 1