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Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males
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SYSNO ASEP 0531956 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Intramuscular short-chain acylcarnitines in elderly people are decreased in (pre-)frail females, but not in males Author(s) van der Hoek, M. D. (NL)
Nieuwenhuizen, A. G. (NL)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Bos, P. (NL)
Palůchová, Veronika (FGU-C) ORCID, RID
Verschuren, L. (NL)
van den Hoek, A. M. (NL)
Kleemann, R. (NL)
Veeger, N. J. G. M. (NL)
van der Leij, F. R. (NL)
Keijer, J. (NL)Source Title FASEB Journal. - : Wiley - ISSN 0892-6638
Roč. 34, č. 9 (2020), s. 11658-11671Number of pages 14 s. Language eng - English Country US - United States Keywords acetylcarnitine ; carnitine ; frailty ; physical function ; mitochondrial dysfunction ; mitochondrial energy production Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition OECD category Endocrinology and metabolism (including diabetes, hormones) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000552096600001 EID SCOPUS 85088014588 DOI 10.1096/fj.202000493R Annotation This study tested the hypothesis that in human aging, a decreased intramuscular acylcarnitine status is associated with (pre‐)frailty, reduced physical performance, and altered mitochondrial function. We used a cross‐sectional study design with well‐matched fit and (pre‐)frail old males and females, using young males and females as healthy controls. Frailty was assessed according to the Fried criteria and physical performance was determined by 400 m walk test, short physical performance battery and handgrip strength. Muscle and plasma acylcarnitine status, and muscle mitochondrial gene expression was analyzed. Results showed that intramuscular total carnitine levels and short‐chain acylcarnitine levels were lower in (pre‐)frail old females compared to fit old females and young females, whereas no differences were observed in males. The low intramuscular short‐chain acylcarnitine levels in females correlated with low physical performance, even after correction for muscle mass (%), and were accompanied with lowered expression of genes involved in mitochondrial energy production and functionality. It is, therefore, concluded that in (pre‐)frail old females, intramuscular total carnitine levels and short‐chain acylcarnitine levels are decreased, and this decrease is associated with reduced physical performance and low expression of a wide range of genes critical for mitochondrial function. The results stress the importance of taking sex differences into account in aging research. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202000493R
Number of the records: 1