Number of the records: 1
Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS
- 1.
SYSNO ASEP 0531420 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS Author(s) Španěl, Patrik (UFCH-W) RID, ORCID
Smith, D. (GB)Source Title Clinical mass spectrometry. - : Elsevier - ISSN 2376-9998
Roč. 16, APR 2020 (2020), s. 18-24Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords trace gas-analysis ; total-body water ; organic-compounds ; healthy-volunteers ; bowel-disease ; reagent ions ; online ; headspace ; series ; h3o+ ; sift-ms ; Breath VOCs ; Metabolites ; Biomarkers Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Method of publishing Limited access Institutional support UFCH-W - RVO:61388955 UT WOS 000539276700003 EID SCOPUS 85079896166 DOI 10.1016/j.clinms.2020.02.001 Annotation Selected ion flow tube mass spectrometry, SIFT-MS, is a non-separative method for direct quantitative analyses of volatile compounds, VOCs, in air and humid breath based on chemical ionization. Selected reagent ions, either H3O+, NO+ or O-2(+) (non-reactive with major components of air), ionize analyte molecules during a defined time in a flow tube by ion-molecule reactions thus producing analyte ions that are characteristic of the neutral analyte VOCs. Concentrations can be calculated in real-time from the ion count rates. Direct on-line analysis of single or multiple breath exhalations or off-line analysis of breath samples collected into bags can be performed. Several volatile breath metabolites have been quantified by SIFT-MS, including ammonia, acetone, hydrogen cyanide, alcohols, pentane, acetic acid, methane, and sulphur compounds. Their potential as biomarkers is discussed. (C) 2020 Published by Elsevier B.V. on behalf of The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL). Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0310084
Number of the records: 1