Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates

Gelle, D.; Lamač, Martin; Mach, Karel; Šimková, Ludmila; Gyepes, R.; Sommerová, L.; Martišová, A.; Bartošík, M.; Vaculovič, T.; Kanický, V.; Hrstka, R.; Pinkas, Jiří

doi:https://dx.doi.org/10.1002/cplu.202000022

Number of the records: 1

Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates

1.

SYSNO ASEP	0524777
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Enhanced Intracellular Accumulation and Cytotoxicity of Ferrocene-Ruthenium Arene Conjugates
Author(s)	Gelle, D. (SK) Lamač, Martin (UFCH-W)_{RID, ORCID, SAI} Mach, Karel (UFCH-W)_{ORCID, RID} Šimková, Ludmila (UFCH-W)_{RID, ORCID} Gyepes, R. (SK) Sommerová, L. (CZ) Martišová, A. (CZ) Bartošík, M. (CZ) Vaculovič, T. (CZ) Kanický, V. (CZ) Hrstka, R. (CZ) Pinkas, Jiří (UFCH-W)_{RID, ORCID}
Source Title	ChemPlusChem. - : Wiley - ISSN 2192-6506 Roč. 85, č. 5 (2020), s. 1034-1043
Number of pages	10 s.
Language	eng - English
Country	DE - Germany
Keywords	antitumor agents ; electrochemistry ; ferrocene ; metallocene ; ruthenium
Subject RIV	CF - Physical ; Theoretical Chemistry
OECD category	Physical chemistry
R&D Projects	GA17-05838S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UFCH-W - RVO:61388955
UT WOS	000536506200031
EID SCOPUS	85085505631
DOI	10.1002/cplu.202000022
Annotation	Coordination of arenophilic CpRu+ (Cp=η5-C5Me5) fragment to pendant aromatic ring(s) of either benzylferrocene (1) or dibenzylferrocene (2) gave air- and water-stable dinuclear (4) or trinuclear (6) ferrocene-ruthenium conjugates. The complexes were characterized by NMR, ESI-MS, cyclic voltammetry (CV), elemental analysis, and the molecular structure of 4 was established by single crystal X-ray diffraction. Contrary to the starting ferrocenes 1 and 2, conjugates 4 and 6 showed significant in vitro anticancer activity (up to IC50 0.6±0.2 μM) against various cancer cell lines (A2780, SK-OV-3, MDA-MB-231). Differential pulse voltammetry (DPV) showed that the intracellular accumulation of 4 was approximately twice that of 6 in all studied cell lines, which corresponds to a higher cytotoxicity of 4.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2021
Electronic address	http://hdl.handle.net/11104/0309069

Number of the records: 1