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Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women
- 1.0524170 - FGÚ 2021 RIV NL eng J - Journal Article
Březinová, Marie - Čajka, Tomáš - Oseeva, Marina - Štěpán, M. - Daďová, K. - Rossmeislová, L. - Matouš, M. - Šiklová, M. - Rossmeisl, Martin - Kuda, Ondřej
Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women.
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. Roč. 1865, č. 2 (2020), č. článku 158576. ISSN 1388-1981. E-ISSN 1879-2618
R&D Projects: GA MZd(CZ) NV16-29182A; GA MŠMT(CZ) LTAUSA17173; GA ČR(CZ) GJ17-10088Y
Grant - others:AV ČR(CZ) LQ200111901
Program: Prémie Lumina quaeruntur
Institutional support: RVO:67985823
Keywords : lipidomics * mass spectrometry * exercise * omega-3 fatty acids * adipose tissue * PAHSA * FAHFA * lipokine * elderly women * ether lipids * FAHFA-TG
OECD category: Endocrinology and metabolism (including diabetes, hormones)
Impact factor: 4.698, year: 2020
Method of publishing: Limited access
https://doi.org/10.1016/j.bbalip.2019.158576
Adverse effects of aging can be delayed with life-style interventions. We examined how exercise training (ET) alone or combined with omega-3 polyunsaturated fatty acid (PUFA) affects serum and adipose tissue (AT) lipidome in older women. Fifty-five sedentary older women were included in the physical activity program and given either sunflower (Placebo) or wax esters-rich (Calanus) oil capsules for 4 months. Serum and subcutaneous abdominal AT samples were acquired while maximum rates of oxygen consumption (VO2 max), insulin sensitivity (hyperinsulinemic-euglycemic clamps) and comprehensive lipidome profiles were determined before and after the study. ET increased VO2 max in both groups. Lipidomics profiling revealed unusual serum triacylglycerols and phospholipids with ether-bound alkyls in the Calanus group, while ET generally induced shorter-chain triacylglycerols in AT, suggesting increased de novo lipogenesis. The latter was positively associated with whole-body insulin sensitivity. Unexpectedly, insulin-sensitizing lipokines from the family of branched palmitic acid esters of hydroxy stearic acid (PAHSAs) were elevated in both serum and AT after ET, while PAHSAs-containing triacylglycerols were detected in AT. ET stimulated beneficial changes in AT, including PAHSAs synthesis. Although the added value of omega-3 PUFA supplementation was not proven, our discovery can help understand the nature of the metabolic benefits of exercise.
Permanent Link: http://hdl.handle.net/11104/0308533
Number of the records: 1