Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

Cutova, M.; Manta, J.; Porubiakova, O.; Kaura, P.; Šťastný, J.; Jagelská, Eva; Goswami, Pratik; Bartas, M.; Brázda, Václav

doi:https://dx.doi.org/10.1016/j.ygeno.2019.11.002

Number of the records: 1

Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae

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SYSNO ASEP	0523977
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Divergent distributions of inverted repeats and G-quadruplex forming sequences in Saccharomyces cerevisiae
Author(s)	Cutova, M. (CZ) Manta, J. (CZ) Porubiakova, O. (CZ) Kaura, P. (CZ) Šťastný, J. (CZ) Jagelská, Eva (BFU-R) Goswami, Pratik (BFU-R) Bartas, M. (CZ) Brázda, Václav (BFU-R)_{RID, ORCID}
Number of authors	9
Source Title	Genomics. - : Elsevier - ISSN 0888-7543 Roč. 112, č. 2 (2020), s. 1897-1901
Number of pages	5 s.
Publication form	Print - P
Language	eng - English
Country	US - United States
Keywords	web-based server ; nucleic-acids ; dna ; binding ; transcription
Subject RIV	EB - Genetics ; Molecular Biology
OECD category	Genetics and heredity (medical genetics to be 3)
R&D Projects	GA18-15548S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	BFU-R - RVO:68081707
UT WOS	000514071600093
EID SCOPUS	85075470548
DOI	10.1016/j.ygeno.2019.11.002
Annotation	The importance of DNA structure in the regulation of basic cellular processes is an emerging field of research. Among local non-B DNA structures, inverted repeat (IR) sequences that form cruciforms and G-rich sequences that form G-quadruplexes (G4) are found in all prokaryotic and eukaryotic organisms and are targets for regulatory proteins. We analyzed IRs and G4 sequences in the genome of the most important biotechnology microorganism, S. cerevisiae. IR and G4-prone sequences are enriched in specific genomic locations and differ markedly between mitochondrial and nuclear DNA. While G4s are overrepresented in telomeres and regions surrounding tRNAs, IRs are most enriched in centromeres, rDNA, replication origins and surrounding tRNAs. Mitochondrial DNA is enriched in both IR and G4-prone sequences relative to the nuclear genome. This extensive analysis of local DNA structures adds to the emerging picture of their importance in genome maintenance, DNA replication and transcription of subsets of genes.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/pii/S0888754319305269?via%3Dihub

Number of the records: 1