Number of the records: 1  

Advances in Disease Models

  1. 1.
    SYSNO ASEP0523240
    Document TypeM - Monograph Chapter
    R&D Document TypeMonograph Chapter
    TitleExploring avian cancer genome with insertional mutagenesis screens using myeloblastosis associated viruses
    Author(s) Pečenka, Vladimír (UMG-J)
    Pajer, Petr (UMG-J)
    Karafiát, Vít (UMG-J)
    Dvořák, Michal (UMG-J) RID
    Source TitleAdvances in Disease Models. - Praha : OPTIO CZ, 2019 / Bartůněk Petr - ISBN 978-80-88011-06-4
    Pagess. 189-206
    Number of pages18 s.
    Number of copy50
    Number of pages310
    Publication formPrint - P
    Languageeng - English
    CountryCZ - Czech Republic
    Keywordschicken retrovirus myeloblastosis-associated virus-2 ; insertional mutagenesis ; oncogenesis
    Subject RIVEB - Genetics ; Molecular Biology
    OECD categoryVirology
    R&D ProjectsLO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportUMG-J - RVO:68378050
    AnnotationWe have established a new model for studying cancer genetics based on insertional mutagenesis by chicken retrovirus myeloblastosis-associated virus-2 (MAV-2) and tumor-promoting agents that target tumorigenesis into individual organs. Using high-performance iPCR we analyzed a large number of chicken tumors, pinpointed common provirus-insertion sites and associated them with candidate cancer genes. So far, we have defined the principal oncogenes driving formation of chicken nephroblastomas (FOXP1, PLAG1, TWIST or HRAS), lung hemangiosarcomas (FRK), liver hemangiosarcomas (HRAS), hepatocarcinomas (EGFR), and cholangiocarcinomas (HGFR or MST1R)(1-4). All of them are now proven human oncogenes, in three cases (TWIST, FOXP1, FRK), our findings preceded the discovery of their involvement in human tumors. This shows that non-mouse species are good alternative models for studying oncogenesis with outcomes applicable to human medicine.
    WorkplaceInstitute of Molecular Genetics
    ContactNikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
    Year of Publishing2020
Number of the records: 1  

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