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Nuclear Phosphoinositides-Versatile Regulators of Genome Functions
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SYSNO ASEP 0521616 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nuclear Phosphoinositides-Versatile Regulators of Genome Functions Author(s) Castano, Enrique (UMG-J)
Yildirim, Sukriye (UMG-J)
Fáberová, Veronika (UMG-J)
Krausová, Alžběta (UMG-J)
Uličná, Lívia (UMG-J)
Paprčková, Darina (UMG-J) ORCID, RID
Sztacho, Martin (UMG-J) ORCID
Hozák, Pavel (UMG-J) RID, ORCIDNumber of authors 8 Source Title Cells. - : MDPI
Roč. 8, č. 7 (2019)Number of pages 19 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords phosphoinositides ; cell nucleus ; genome ; gene expression Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA17-09103S GA ČR - Czech Science Foundation (CSF) GA19-05608S GA ČR - Czech Science Foundation (CSF) TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000478902000041 DOI 10.3390/cells8070649 Annotation The many functions of phosphoinositides in cytosolic signaling were extensively studied, however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2's role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2020 Electronic address https://www.mdpi.com/2073-4409/8/7/649
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