Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells

0520858 - BFÚ 2020 RIV GR eng J - Journal Article
Bartas, M. - Cerven, J. - Oppelt, J. - Peteja, M. - Vavra, P. - Zonca, P. - Procházka, V. - Brázda, Václav - Pečinka, P.
Liver regeneration during the associating liver partition and portal vein ligation for staged hepatectomy procedure in Sus scrofa is positively modulated by stem cells.
Oncology Letters. Roč. 15, č. 5 (2018), s. 6309-6321. ISSN 1792-1074. E-ISSN 1792-1082
Institutional support: RVO:68081707
Keywords : animal-models * fibrosis * expression * growth * therapy
OECD category: Oncology
Impact factor: 1.871, year: 2018
Method of publishing: Open access
http://www.spandidos-publications.com/10.3892/ol.2018.8108/download

This present study investigated the impact of the application of stem cells to liver regeneration following the first stage of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). The experiment was conducted on a pig model (n=6, 3 that did not receive application of stem cells, 3 that received application stem cells). Collected samples of liver (day 0 and 9 following surgery) were subjected to complete transcriptome sequencing. In total, 39 differentially expressed genes were found in the group without the application of the stem cells (genes of unwanted processes such as fibrosis and inflammation). In the group that did receive application of stem cells, no significantly differentially expressed genes were found, indicating a properly regenerated liver remnant. The present study therefore demonstrated, to the best of our knowledge for the first time, the positive effect of stem cells application in the liver regeneration process during ALPPS procedure in the pig model.
Permanent Link: http://hdl.handle.net/11104/0305519