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Harmless glucose-modified ruthenium complexes suppressing cell migration of highly invasive cancer cell lines
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SYSNO ASEP 0520528 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Harmless glucose-modified ruthenium complexes suppressing cell migration of highly invasive cancer cell lines Author(s) Lamač, Martin (UFCH-W) RID, ORCID, SAI
Horáček, Michal (UFCH-W) RID, ORCID
Červenková Šťastná, Lucie (UCHP-M) RID, ORCID, SAI
Karban, Jindřich (UCHP-M) RID, ORCID, SAI
Sommerová, L. (CZ)
Skoupilová, H. (CZ)
Hrstka, R. (CZ)
Pinkas, Jiří (UFCH-W) RID, ORCIDArticle number e5318 Source Title Applied Organometallic Chemistry. - : Wiley - ISSN 0268-2605
Roč. 34, č. 1 (2020)Number of pages 5 s. Language eng - English Country GB - United Kingdom Keywords in-vitro ; metastasis ; progression ; mechanism ; drugs ; cancer ; glucose ; metallodrugs ; migrastatic ; organometallic ruthenium complexes Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Subject RIV - cooperation Institute of Chemical Process Fundamentals - Organic Chemistry R&D Projects GA17-05838S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UFCH-W - RVO:61388955 ; UCHP-M - RVO:67985858 UT WOS 000496827400001 EID SCOPUS 85075152486 DOI 10.1002/aoc.5318 Annotation Glucose-substituted ruthenium complexes [(eta(6)-benzyl-glucose)RuCp*]Cl-+(-), where Cp* = eta(5)-C5Me5, benzyl-glucose = peracetylated benzyl beta-d-glucopyranoside (1), benzyl beta-d-glucopyranoside (2), have been prepared and used as efficient antimigration and anti-invasive agents against metastatic breast cancer cells (MDA-MB-231) and cisplatin-resistant ovarian cancer cells (SK-OV-3). In addition, these complexes were found to be essentially non-toxic against non-cancerous human kidney cells (HEK293). Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0305192
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