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Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair
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SYSNO ASEP 0518443 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Dynamic creep properties of a novel nanofiber hernia mesh in abdominal wall repair Author(s) East, B. (CZ)
Plencner, Martin (UEM-P)
Otáhal, M. (CZ)
Amler, E. (CZ)
de Beaux, A.C. (GB)Source Title Hernia. - : Springer - ISSN 1265-4906
Roč. 23, č. 5 (2019), s. 1009-1015Number of pages 7 s. Language eng - English Country FR - France Keywords nanofibres ; PCL ; hernia Subject RIV EI - Biotechnology ; Bionics OECD category Biophysics Method of publishing Limited access Institutional support UEM-P - RVO:68378041 UT WOS 000495397400020 EID SCOPUS 85064496355 DOI https://doi.org/10.1007/s10029-019-01940-w Annotation PurposeIncisional hernia is the most common complication following abdominal surgery. While mesh repair is common, none of the current meshes mimic the physiology of the abdominal wall. This study compares suture only repair with polypropylene mesh and a prototype of a novel implant (poly-epsilon-caprolactone nanofibers) and their influence on the physiology of an abdominal wall in an animal model.Methods27 Chinchilla rabbits were divided into six groups based on the type of the implant. Midline abdominal incision was repaired using one of the compared materials with suture alone serving as the control. 6 weeks post-surgery animals were killed and their explanted abdominal wall subjected to biomechanical testing.ResultsBoth-hysteresis and maximum strength curves showed high elasticity and strength in groups where the novel implant was used. Polypropylene mesh proved as stiff and fragile compared to other groups.ConclusionPoly-epsilon-caprolactone nanofiber scaffold is able to improve the dynamic properties of healing fascia with no loss of maximum tensile strength when compared to polypropylene mesh in an animal model. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2020 Electronic address https://link.springer.com/article/10.1007%2Fs10029-019-01940-w
Number of the records: 1