Prolactin-releasing peptide: Physiological and pharmacological properties

0511196 - ÚOCHB 2020 RIV CH eng J - Journal Article
Pražienková, Veronika - Popelová, Andrea - Kuneš, Jaroslav - Maletínská, Lenka
Prolactin-releasing peptide: Physiological and pharmacological properties.
International Journal of Molecular Sciences. Roč. 20, č. 21 (2019), č. článku 5297. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA18-10591S
Institutional support: RVO:61388963
Keywords : prolactin-releasing peptide * GPR10 * RF-amide peptides * food intake regulation * energy expenditure * neuroprotection * signaling
OECD category: Biochemistry and molecular biology
Impact factor: 4.556, year: 2019
Method of publishing: Open access
https://www.mdpi.com/1422-0067/20/21/5297

Prolactin-releasing peptide (PrRP) belongs to the large RF-amide neuropeptide family with a conserved Arg-Phe-amide motif at the C-terminus. PrRP plays a main role in the regulation of food intake and energy expenditure. This review focuses not only on the physiological functions of PrRP, but also on its pharmacological properties and the actions of its G-protein coupled receptor, GPR10. Special attention is paid to structure-activity relationship studies on PrRP and its analogs as well as to their effect on different physiological functions, mainly their anorexigenic and neuroprotective features and the regulation of the cardiovascular system, pain, and stress. Additionally, the therapeutic potential of this peptide and its analogs is explored.
Permanent Link: http://hdl.handle.net/11104/0301532