Determination of optical purity of lactic acid-based chiral liquid crystals and corresponding building blocks by chiral high-performance liquid chromatography and supercritical fluid chromatography

0511153 - FZÚ 2020 RIV CH eng J - Journal Article
Poryvai, A. - Jurkovičová, Terézia - Šmahel, M. - Kolderová, N. - Tomášková, Petra - Sýkora, D. - Kohout, M.
Determination of optical purity of lactic acid-based chiral liquid crystals and corresponding building blocks by chiral high-performance liquid chromatography and supercritical fluid chromatography.
Molecules. Roč. 24, č. 6 (2019), s. 1-11, č. článku 1099. E-ISSN 1420-3049
Institutional support: RVO:68378271
Keywords : chiral liquid crystals * optical purity * chiral separation * supercritical fluid chromatography * enantioseparation of liquid crystals
OECD category: Analytical chemistry
Impact factor: 3.267, year: 2019
Method of publishing: Open access

In this study we aimed to verify synthetic methods of liquid crystals (LCs) recently published in the literature, which are used nowadays to prepare chiral building blocks based on lactic acid, for their enantioselectivity. We have focused on the development of an analytical chiral separation method for target liquid crystalline materials. Using a chiral polysaccharide-based column operated in liquid chromatography mode, we show that not all published methods of LC synthesis are enantioselective, which could lead to significant differences in the properties of the resulting materials. We show that high-performance liquid chromatography with UV detection and supercritical fluid chromatography with UV and mass spectrometry detection enable full control over the chemical and optical purity of the target LCs and the corresponding chiral building blocks.
Permanent Link: http://hdl.handle.net/11104/0301482