Number of the records: 1  

Activation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis

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    SYSNO ASEP0510897
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleActivation of the Ataxia Telangiectasia Mutated/Autophagy pathway by a G-quadruplex ligand links senescence with apoptosis
    Author(s) Beauvarlet, J. (FR)
    Mergny, Jean-Louis (BFU-R) ORCID, RID
    Djavaheri-Mergny, M. (FR)
    Number of authors3
    Article numbere1604047
    Source TitleMolecular & Cellular Oncology. - : Taylor & Francis - ISSN 2372-3556
    Roč. 6, č. 4 (2019)
    Number of pages3 s.
    Publication formOnline - E
    Languageeng - English
    CountryUS - United States
    Keywordsautophagy ; damage ; Cancer therapy ; G-quadruplex ; autophagy
    Subject RIVFD - Oncology ; Hematology
    OECD categoryOncology
    R&D ProjectsEF15_003/0000477 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    Method of publishingLimited access
    Institutional supportBFU-R - RVO:68081707
    UT WOS000471962100004
    DOI10.1080/23723556.2019.1604047
    AnnotationG-quadruplex (G4) ligands have shown anti-tumor activity by stabilizing G4 structures. We recently reported that the G4 ligand 20A promotes senescence in cancer cells through Ataxia Telangiectasia Mutated (ATM) and autophagy activation. Inhibition of both pathways directs cells to apoptosis, positioning ATM/autophagy axis as a linchpin between senescence and apoptosis.
    WorkplaceInstitute of Biophysics
    ContactJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Year of Publishing2020
    Electronic addresshttps://www.tandfonline.com/doi/full/10.1080/23723556.2019.1604047
Number of the records: 1  

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