Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin

0510188 - BFÚ 2020 RIV DE eng J - Journal Article
Novohradský, Vojtěch - Rovira, M.G. - Hally, C. - Galindo, A. - Vigueras, G. - Gandioso, A. - Svitelova, M. - Bresoli-Obach, R. - Kostrhunová, Hana - Marková, Lenka - Kašpárková, Jana - Nonell, S. - Ruiz, J. - Brabec, Viktor - Marchan, V.
Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir-III Complex Conjugated to a Far-Red Emitting Coumarin.
Angewandte Chemie - International Edition. Roč. 58, č. 19 (2019), s. 6311-6315. ISSN 1433-7851. E-ISSN 1521-3773
R&D Projects: GA ČR(CZ) GA18-09502S
Institutional support: RVO:68081707
Keywords : iridium(iii) complexes * ir(iii) complexes * bodipy ligands * therapy * photosensitizers * conjugation
OECD category: Physical chemistry
Impact factor: 12.959, year: 2019
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901268

Although cyclometalated Ir-III complexes have emerged as promising photosensitizers for photodynamic therapy, some key drawbacks still hamper clinical translation, such as operability in the phototherapeutic window and reactive oxygen species (ROS) production efficiency and selectivity. In this work, a cyclometalated Ir-III complex conjugated to a far-red-emitting coumarin, Ir-III-COUPY, is reported with highly favourable properties for cancer phototherapy. Ir-III-COUPY was efficiently taken up by HeLa cells and showed no dark cytotoxicity and impressive photocytotoxicity indexes after irradiation with green and blue light, even under hypoxia. Importantly, a clear correlation between cell death and intracellular generation of superoxide anion radicals after visible light irradiation was demonstrated. This strategy opens the door to novel fluorescent photodynamic therapy agents with promising applications in theragnosis.
Permanent Link: http://hdl.handle.net/11104/0300714