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Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents
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SYSNO ASEP 0509934 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents Author(s) Šťastný, Martin (UACH-T) SAI, RID
Štengl, Václav (UACH-T) RID, ORCID, SAI
Štenglová Netíková, I. R. (CZ)
Šrámová Slušná, Michaela (UACH-T) SAI
Janoš, P. (CZ)Number of authors 5 Article number 0223117 Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 14, č. 10 (2019)Number of pages 25 s. Language eng - English Country US - United States Keywords titanium dioxide nanoparticle ; anthracyclines ; sodium hydroxide Subject RIV CA - Inorganic Chemistry OECD category Inorganic and nuclear chemistry Method of publishing Open access Institutional support UACH-T - RVO:61388980 UT WOS 000530285000001 EID SCOPUS 85073157915 DOI 10.1371/journal.pone.0223117 Annotation Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5-120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively. Workplace Institute of Inorganic Chemistry Contact Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Year of Publishing 2020 Electronic address http://hdl.handle.net/11104/0300522
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