Investigation of Cell Mobility and Deformability

0508612 - ÚIACH 2020 FR eng A - Abstract
Klepárník, Karel - Ledvina, Vojtěch - Legartová, Soňa - Bártová, Eva
Investigation of Cell Mobility and Deformability.
ITP 2019. Book of Abstracts. Francie: University Paul Sabatier, 2019. s. 64-64.
[ITP 2019. International Symposium on Electroseparation and Liquid Phase-Separation Techniques /26./. 01.09.2019-04.09.2019, Toulouse]
R&D Projects: GA ČR(CZ) GA17-01995S
Institutional support: RVO:68081715
Keywords : cell mobility * cancer metastasis * microfluidic device
OECD category: Analytical chemistry

We have developed a chamber for the testing of cell mobility in chemoattractant concentration gradient together with deformability in variable concentration gradient together with deformability in variable constraint space. In the miniaturized device with the total migration path length less than 1 mm, the analysis time was substantially shortened, when compared with commonly used instrumentation. The described device has the potential to be implemented in personalized medicine for testing tendency of patients´tumours to metastasis. Not only cancer metastasis but also other physiological phenomena like wound healing and tissue growt can be investigated this way.
Permanent Link: http://hdl.handle.net/11104/0299480