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Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
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SYSNO ASEP 0508104 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests Author(s) Meccariello, A. (IT)
Salvemini, M. (IT)
Primo, P. (IT)
Hall, B. (US)
Koskinioti, P. (AT)
Dalíková, Martina (BC-A) RID, ORCID
Gravina, A. (IT)
Gucciardino, M. A. (IT)
Forlenza, F. (IT)
Gregoriou, M.-E. (GR)
Ippolito, D. (IT)
Monti, S. M. (IT)
Petrella, V. (IT)
Perrotta, M. M. (IT)
Schmeing, S. (CH)
Ruggiero, A. (IT)
Scolari, F. (IT)
Giordino, E. (IT)
Tsoumani, K. T. (GR)
Marec, František (BC-A) RID, ORCID
Windibichler, N. (GB)
Arunkumar, K. P. (IN)
Bourtzis, K. (AT)
Mathiopoulos, K. D. (GR)
Ragoussis, J. (CA)
Vitaglino, L. (IT)
Tu, Z. (US)
Papathanos, P. A. (IT)
Robinson, M. D. (CH)
Saccone, G. (IT)Number of authors 30 Source Title Science. - : American Association for the Advancement of Science - ISSN 0036-8075
Roč. 365, č. 6460 (2019), s. 1457-1460Number of pages 4 s. Language eng - English Country US - United States Keywords medfly ; male sex determination ; Y chromosome Subject RIV EB - Genetics ; Molecular Biology OECD category Genetics and heredity (medical genetics to be 3) R&D Projects GA17-13713S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000488838600049 EID SCOPUS 85072710875 DOI https://doi.org/10.1126/science.aax1318 Annotation In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, Medfly) we identified a Y-linked gene, Maleness-on the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization whereas overexpression of MoY in XX embryos induces masculinization. Crosses between transformed XY females and XX males give rise to males and females, indicating that a Y chromosome can be transmitted by XY females. MoY is Y-linked and functionally conserved in other species of the Tephritidae family, highlighting its potential to serve as a tool for developing more effective control strategies against these major agricultural insect pests. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2020 Electronic address https://science.sciencemag.org/content/365/6460/1457
Number of the records: 1